Bluepharma

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Publicações Científicas

Blue - Revista Bluepharma

Presskit

Brochuras

Brochura Institucional

With eyes set on the future

17/05/2023.8.9 MB

Development & Manufacturing

Your partner that cares

25/04/2023.7.6 MB

Product Portfolio

Develpoment and Licensing Opportunities

25/04/2023.8.3 MB

Value Added Medicines

Oromucosal Delivery, Complex Steriles and OSD Fixed-Dose Combinations

25/04/2023.6.1 MB

ONConcept®

A strategic collaboration in the field of oncology

11/10/2022.5.8 MB

Publicações Científicas

Oromucosal products – Market landscape and innovative technologies: A review

Francisca Bastos, Ana Catarina Pinto, António Nunes, Sérgio Simões

07/06/2022

Molecular structure, spectroscopy and photochemistry of alprazolam

13/08/2021

Hot-Melt Extrusion: a Roadmap for Product Development

16/06/2021

Medication adherence in older people with rheumatoid arthritis is lower according to electronic monitoring than according to pill count

03/03/2021

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

15/02/2021

Amphiphilic well-defined degradable star block copolymers by combination of ring-opening polymerization and atom transfer radical polymerization: Synthesis and application as drug delivery carriers

18/01/2021

Artificial neural networks applied to quality-by-design: From formulation development to clinical outcome

18/05/2020

Enhanced solid-state stability of amorphous ibrutinib formulations prepared by hot-melt extrusion

16/02/2020

Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives

17/12/2019

Five-Stage Approach for a Systematic Screening and Development of Etravirine Amorphous Solid Dispersions by Hot-Melt Extrusion

27/11/2019

Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

24/05/2019

Orphan drugs: major development challenges at the clinical stage

15/01/2019

Critical process parameters of orodispersible films (ODFs)

13/02/2018

Intradermal Delivery of a Near-Infrared Photosensitizer Using Dissolving Microneedle Arrays

31/05/2018

Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique

15/06/2017

Retrospective Quality by Design (rQbD) applied to the optimization of orodispersible films

16/06/2017

A first in human study using photodynamic therapy with Redaporfin in advanced head and neck cancer

30/04/2017

Ultrafast Dynamics of Manganese(III), Manganese(II), and Free-Base Bacteriochlorin: Is There Time for Photochemistry?

16/02/2017

The use of liposomes for the systemic delivery of RNAi therapeutics aiming at cancer treatment

15/01/2016

Outlining critical quality attributes (CQAs) as guidance for the development of orodispersible films

26/06/2016

Hydrophobic polymers for orodispersible films: a quality by design approach

29/03/2016

Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination

05/08/2015

Intravenous Single-Dose Toxicity of Redaporfin-Based Photodynamic Therapy in Rodents

08/12/2015

Mucoadhesive oral films: The potential for unmet needs

23/08/2015

Elimination of primary tumours and control of metastasis with rationally designed bacteriochlorin photodynamic therapy regimens

25/06/2015

Oral films: Current status and future perspectives II — Intellectual property, technologies and market needs

14/03/2015

Oral films: Current status and future perspectives: I — Galenical development and quality attributes

05/03/2015

Polymeric bile acid sequestrants—Synthesis using conventional methods and new approaches based on “controlled”/living radical polymerization

17/09/2012

Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination

10/10/2014

Manufacturing and export provisions: Impact on the competitiveness of European pharmaceutical manufacturers and on the creation of jobs in Europe

08/10/2014

Photodynamic Therapy Efficacy Enhanced by Dynamics: The Role of Charge Transfer and Photostability in the Selection of Photosensitizers

18/03/2014

Modulation of Biodistribution, Pharmacokinetics, and Photosensitivity with the Delivery Vehicle of a Bacteriochlorin Photosensitizer for Photodynamic Therapy

27/12/2013

Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform

28/08/2013

Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer

29/07/2011

Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

18/05/2012

Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

07/05/2012

Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: Evidence from intracellular fluorescence and increased photodynamic efficacy in vitro

13/01/2012

Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations

30/04/2012

Tissue Uptake Study and Photodynamic Therapy of Melanoma-Bearing Mice with a Nontoxic, Effective Chlorin

04/07/2011

Biodistribution and Photodynamic Efficacy of a Water-Soluble, Stable, Halogenated Bacteriochlorin against Melanoma

24/01/2011

Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy

08/04/2010

Targeting non-viral vectors to tumor cells and the tumor microenvironment

23/09/2010

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

13/07/2010

Synthesis and photophysical characterization of a library of photostable halogenated bacteriochlorins: an access to near infrared chemistry

11/10/2010

New Halogenated Water-Soluble Chlorin and Bacteriochlorin as Photostable PDT Sensitizers: Synthesis, Spectroscopy, Photophysics, and in vitro Photosensitizing Efficacy

15/08/2010

Mechanisms of Singlet-Oxygen and Superoxide-Ion Generation by Porphyrins and Bacteriochlorins and their Implications in Photodynamic Therapy

29/07/2010

Liposomal imatinib–mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer

23/11/2010

Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner

23/12/2008

Synthesis and photophysical properties of amphiphilic halogenated bacteriochlorins: new opportunities for photodynamic therapy of cancer

30/09/2009

Non-Viral Lipid-Based Nanoparticles for Targeted Cancer Systemic Gene Silencing

30/04/2008

Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients

21/03/2008

Cationic liposomes for gene delivery

11/05/2005

Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells

23/11/2004

On the formulation of pH-sensitive liposomes with long circulation times

26/01/2004

Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles

06/12/2001

The Gloria Adherence Subproject: Problems and Randomization Mistakes

17/10/2021

Blue - Revista Bluepharma

A Blue é feita a pensar, sobretudo, nos nossos stakeholders, pretendendo refletir a evolução e as conquistas da Bluepharma ao longo destes 20 anos. Uma publicação anual bilingue, em Português e Inglês, que está disponível em formato digital dinâmico (com links e vídeos integrados) e em formato impresso.